Hepatitis E virus (HEV) is a common etiology of acute viral hepatitis worldwide. Recombinant HEV vaccines have been developed,\nbut only one is commercially available and licensed in China since 2011. Epidemiological studies have identified genotype 3 as the\nmajor cause of chronic infection in immunocompromised individuals. Ribavirin has been shown to be effective as a monotherapy\nto induce HEV clearance in chronic patients who have undergone solid organ transplant (SOT) under immunosuppressive therapy.\nEfforts and improvements in prevention and control have been made to reduce the instances of acute and chronic hepatitis E in\nendemic and nonendemic countries. However, this review shows that further studies are required to demonstrate the importance\nof preventive vaccination and treatment worldwide, with emphasis on hepatitis E infection in the public health system.
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